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| Episode 1 - [My Jerks] |
| Details : Dr. Kelso's beautiful but unethical replacement Dr. Maddox shakes things up at Sacred Heart while J.D. struggles to manage a new crop of incompetent interns and Carla helps Elliott put her ego in check. |
| Guest Cast and Crew : Taran Killam as Jimmy | Aziz Ansari as Ed | Courteney Cox as Dr. Maddox | Michael Spiller as The Balloon Guy | Eric Artell as Rodney | Aseem Batra as Josephine | James Ritz as Mr. Hicks | Jack Grinnage as Marvell | Betsy Beutler as Dr. Katie Collins | Sam Lloyd as Ted | Eliza Coupe as Dr. Denise Mahoney | Travis Schuldt as Keith | Director : Michael Spiller | Writer : Angela Nissel | |
| Air Date : Jan. 06, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 2 - [My Last Words] |
| Details : J.D. and Turk make a huge sacrifice concerning a decade-long steak night tradition for a dying patient. Meanwhile Dr. Maddox the new Chief of Medicine begins to show her true colors. |
| Guest Cast and Crew : Glynn Turman as George | Aziz Ansari as Ed | Courteney Cox as Dr. Maddox | Deonte Gordon as Shawn | Manley Henry as Snoop Dawg Attending | Randall Winston as Death | Betsy Beutler as Dr. Katie Collins | Sam Lloyd as Ted | Eliza Coupe as Dr. Denise Mahoney | Travis Schuldt as Keith | Christa Miller as Jordan Sullivan | Writer : Aseem Batra | Director : Bill Lawrence | |
| Air Date : Jan. 06, 2009 | Rating ➦ ★★★★★★★★★ |
| Episode 3 - [My Saving Grace] |
| Details : Dr. Kelso and Dr. Cox have to work together again to get rid of Dr. Maddox while Carla faces an incompetent intern. |
| Guest Cast and Crew : Frank Novak as Pat Rosell | Courteney Cox as Dr. Maddox | Marcus Folmar as Mr. Tillman | Jennifer Jostyn as Dr. Simmons | Annie Little as Christine | Frank Encarnacao as Dr. Mickhead | Betsy Beutler as Dr. Katie Collins | Christa Miller as Jordan Sullivan | Writer : Janae Bakken | Director : Michael Spiller | |
| Air Date : Jan. 13, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 4 - [My Happy Place] |
| Details : J.D. and Elliot's relationship seems to have been rekindled when they encourage Dr. Kelso to find his true happy place. |
| Guest Cast and Crew : Taran Killam as Jimmy | Jack Grinnage as Marvell | Scott Rinker as Mr. Halford | Cathleen Kaelyn as Mrs. Halford | Michael Potter as Patient | Sam Lloyd as Ted | Robert Maschio as Todd | Director : Ken Whittingham | Writer : Taii K. Austin | |
| Air Date : Jan. 13, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 5 - [My Abc's] |
| Details : Featuring a special appearance from Sesame Workshop's Muppets J.D. learns a lesson about the gift of compassion while Elliot gets scammed by intern Katie to secure a spot on Turk's team. |
| Guest Cast and Crew : Aziz Ansari as Ed | Caroll Spinney as Oscar the Grouch (voice) | Julia Campbell as Mrs. Fremont | Eric Jacobson as Grover (voice) | Kevin Clash as Elmo (voice) | David Goryl as Mr. Fremont | Lak Rana as Intern | Stephanie D'Abruzzo as A.M. Muppet (Ex Ray) (voice) | Betsy Beutler as Dr. Katie Collins | Eliza Coupe as Dr. Denise Mahoney | Robert Maschio as Todd | Writer : Bill Lawrence | Director : Bill Lawrence | |
| Air Date : Jan. 27, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 6 - [My Cookie Pants] |
| Details : Elliot and J.D. encounter a road block in their newfound romantic relationship and Dr. Cox considers taking the now vacant Chief of Medicine post. |
| Guest Cast and Crew : Anthony Russell as Mr. Lawton | Eliza Coupe as Dr. Denise Mahoney | Robert Maschio as Todd | Christa Miller as Jordan Sullivan | Writer : Clarence Livingston | Director : Gail Mancuso | |
| Air Date : Jan. 27, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 7 - [My New Role] |
| Details : As his increasing workload from being Chief of Medicine begins to take a toll the unimaginable happens when Dr. Cox reaches out to Dr. Kelso for friendship. |
| Guest Cast and Crew : Frank Encarnacao as Dr. Mickhead | Bob Bencomo as Colonel Doctor | Lewis Dauber as Mr. Vaughn | Helen Geller as Mrs. Fishman | Marcy Minton as Nurse Barbara | Mary Passeri as Nurse Nelly | Betsy Beutler as Dr. Katie Collins | Todd Bosley as Howie | Sam Lloyd as Ted | Robert Maschio as Todd | Director : Will Mackenzie | Writer : Dave Tennant | |
| Air Date : Feb. 03, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 8 - [My Lawyer's In Love] |
| Details : It's Ted's lucky day when he falls head over heels in love with an ukulele player and Dr. Cox realizes he cannot handle everything that is thrown at him. |
| Guest Cast and Crew : Aziz Ansari as Ed | Blair Williamson as Craig | Sam Lloyd as Ted | Philip McNiven as Roy | George Miserlis as Crispin | Paul F. Perry as Randall | Kate Micucci as Stephanie Gooch | Christa Miller as Jordan Sullivan | Writer : Debra Fordham | Director : Mark Stegemann | |
| Air Date : Feb. 03, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 9 - [My Absence] |
| Details : J.D. manages to still bother Dr. Cox despite being away on a vacation from the hospital. Meanwhile Turk and Carla have some big news to announce. |
| Guest Cast and Crew : Marcia Ann Burrs as Peggy | Sonal Shah as Dr. Sunny Day | Eliza Coupe as Dr. Denise Mahoney | Sam Lloyd as Ted | Kate Micucci as Stephanie Gooch | Writer : Debra Fordham | Director : John Putch | |
| Air Date : Feb. 10, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 10 - [My Comedy Show] |
| Details : J.D. and Turk gather up a new crop of interns as they organize their annual (and historically unfunny) sketch show. |
| Guest Cast and Crew : Taran Killam as Jimmy | Julie Pop as Lulu Tarasi | Amanda Thorp as Brianna Tarasi | Geoff Stevenson as Dr. Beardface | Scott Palmason as Dr. Kelso Intern | Daniel Saltos as Dr. Wen Intern | Betsy Beutler as Dr. Katie Collins | Todd Bosley as Howie | Sonal Shah as Dr. Sunny Day | Eliza Coupe as Dr. Denise Mahoney | Robert Maschio as Todd | Aloma Wright as Laverne Roberts | Director : Ted Wass | Writer : Rego Marquiis | Writer : Devin O. Mahoney | |
| Air Date : Feb. 10, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 11 - [My Nah Nah Nah] |
| Details : While Turk views an inspiring story on SportsCenter he comes up with a new procedure which may help a paralyzed teen. Meanwhile Dr. Cox and the janitor are suffering from romantic problems |
| Guest Cast and Crew : Tim DeKay as Mr. Hill | Hannah Storm as Hannah Storm | Phoebe Dorin as Mrs. Jensen | Kit Pongetti as Lady | Andrew Miller as Baby Jack | Bob Clendenin as Dr. Zeltzer | Robert Maschio as Todd | Christa Miller as Jordan Sullivan | Writer : Kevin Biegel | Director : John Putch | Writer : Clarence Livingston | Director : Gail Mancuso | |
| Air Date : Mar. 18, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 12 - [Their Story II] |
| Details : J.D.'s ego becomes inflated after Dr. Cox finally gives him the recognition he's been waiting for. Elsewhere the senior staff receives insight from the interns. |
| Guest Cast and Crew : Lee Thompson Young as Derek | Adam Conger as Charles | Linda Tomassone as Paige | Betsy Beutler as Dr. Katie Collins | Todd Bosley as Howie | Sonal Shah as Dr. Sunny Day | Eliza Coupe as Dr. Denise Mahoney | Robert Maschio as Todd | Director : Michael McDonald | Writer : Andy Schwartz | |
| Air Date : Mar. 25, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 13 - [My Full Moon] |
| Details : A combination of a full moon and some bad luck causes Sacred Heart's new crop of interns to receive their toughest case load yet while Elliot makes an important decision regarding her future as a doctor. |
| Guest Cast and Crew : Tim Moore as Mr. Gold | Lee Thompson Young as Derek | Betsy Beutler as Dr. Katie Collins | Mark Ankeny as Mr. Swick | Debra Fordham as Dr. Fordham | Jean St. James as Mrs. Powell | Sara Van Horn as Mrs. Emmett | Corena Chase as Robyn | Deonte Gordon as Orderly | Todd Bosley as Howie | Sonal Shah as Dr. Sunny Day | Eliza Coupe as Dr. Denise Mahoney | Robert Maschio as Todd | Writer : Kevin Biegel | Director : John Michel | |
| Air Date : Apr. 01, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 14 - [My Soul On Fire Part 1] |
| Details : The Janitor and Lady invite the Sacred Heart staff to their fake wedding in the Bahamas hoping to score some loot but their scheme is about to backfire... |
| Guest Cast and Crew : Barry Williams as Barry Williams | Mike Schwartz as Lloyd | Clark DeVol as Red Headed Kid | Arleen Grace as Woman | Johnny Kastl as Doug Murphy | Cabot McMullen as Med School Professor | Kit Pongetti as Lady | Sam Lloyd as Ted | Randall Winston as Leonard | Robert Maschio as Todd | Christa Miller as Jordan Sullivan | Writer : Bill Callahan | Director : Bill Lawrence | |
| Air Date : Apr. 08, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 15 - [My Soul On Fire Part 1] |
| Details : The tropical seaside wedding goes ahead as the Janitor and Lady tie the knot which affirms the relationship of another couple. |
| Guest Cast and Crew : Bill Lawrence as Justice of the Peace | Johnny Kastl as Doug Murphy | Cabot McMullen as Med School Professor | Shalina Waterman as Mermaid | Kit Pongetti as Lady | Sam Lloyd as Ted | Robert Maschio as Todd | Christa Miller as Jordan Sullivan | Writer : Bill Callahan | Director : Bill Lawrence | |
| Air Date : Apr. 15, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 16 - [My Cuz] |
| Details : Things get weird for J.D. when he discovers the identity of Kim's new man as he plans to reach out to her in order to move closer to Sam. Meanwhile Turk starts a campaign for a promotion. |
| Guest Cast and Crew : Scott Foley as Sean Kelly | Elizabeth Banks as Dr. Kim Briggs | Kit Pongetti as Lady | Todd Bosley as Howie | Korbi Ghosh as Nurse Korbi | Arielle Byron as Barista | Sonal Shah as Dr. Sunny Day | Robert Maschio as Todd | Director : Linda Mendoza | Writer : Kevin Biegel | |
| Air Date : Apr. 22, 2009 | Rating ➦ ★★★★★★★ |
| Episode 17 - [My Chief Concern] |
| Details : Change doesn't come easy for the gang when J.D. considers moving closer to his son. Meanwhile Turk gets comfortable as chief of surgery while Ted and Gooch reach a new level in their relationship. |
| Guest Cast and Crew : Taran Killam as Jimmy | Lee Thompson Young as Derek | Elizabeth Banks as Dr. Kim Briggs | Kit Pongetti as Lady | Nancy Daly as Mrs. Gallin | John Kahle as Ethan | Eliza Coupe as Dr. Denise Mahoney | Sam Lloyd as Ted | Kate Micucci as Stephanie Gooch | Robert Maschio as Todd | Christa Miller as Jordan Sullivan | Director : Zach Braff | Writer : Garrett Donovan | Writer : Neil Goldman | |
| Air Date : May. 05, 2009 | Rating ➦ ★★★★★★★★ |
| Episode 18 - [My Finale Part 1] |
| Details : J.D. is planning on leaving Sacred Heart but before he goes there are a few things that he wants to do including; getting a hug from Dr. Cox and learning the Janitor's real name. Elliot is ready for the next step in her and J.D.'s relationship and she begins moving her furniture into J.D.'s apartment. |
| Guest Cast and Crew : Judy Jean Berns as Mrs. Stonewater | Sonal Shah as Dr. Sunny Day | Eliza Coupe as Dr. Denise Mahoney | Sam Lloyd as Ted | Josh Cooke as Dan | Bob Rumnock as Patient | Robert Maschio as Todd | Christa Miller as Jordan Sullivan | Writer : Bill Lawrence | Director : Bill Lawrence | |
| Air Date : May. 06, 2009 | Rating ➦ ★★★★★★★★★ |
| Episode 19 - [My Finale Part 2] |
| Details : J.D. continues his last day at Sacred Heart and tries to hold out hope for a great sendoff. |
| Guest Cast and Crew : Judy Jean Berns as Mrs. Stonewater | Sonal Shah as Dr. Sunny Day | Eliza Coupe as Dr. Denise Mahoney | Sam Lloyd as Ted | Manley Henry as Snoop Dogg Attending | Bill Lawrence as Janitor | Josh Cooke as Dan | Randall Winston as Leonard | Robert E. Beckwith as Dr. Johnson | Andrew Miller as Baby Jack | Elizabeth Bogush as Alex Hanson | Stephanie D'Abruzzo as Patti | Charles Rahi Chun as Dr. Wen | Bob Clendenin as Dr. Zeltzer | Tom Cavanagh as Dan Dorian | Shaughn Buchholz as Cabbage | Colin Hay as Colin Hay | Phill Lewis as Hooch | Kathryn Joosten as Mrs. Tanner | Amy Smart as Jamie Moyer | Jay Kenneth Johnson as Dr. Matthews | Joe Rose as Troy | Michael Learned as Mrs. Wilk | Nicole Sullivan as Jill Tracy | Martin Klebba as Randall | Michael McDonald as Mike Davis | Travis Schuldt as Keith | Tyler Poelle as Boon | Katie O'Rourke as Coffee Nurse | George Miserlis as Crispin | Philip McNiven as Roy | Paul F. Perry as Randall | Jill Tracy as Elaine | Michael Hobert as Lonnie | Meredith Quill as Kathy | Christina Miles as Gloria | Bob Rumnock as Patient | Lindsay Ravage as Slagathor | Bellamy Young as Dr. Miller | Kate Micucci as Stephanie Gooch | Robert Maschio as Todd | Matt Winston as Jeffrey Steadman | Aloma Wright as Laverne Roberts | Christa Miller as Jordan Sullivan | Writer : Bill Lawrence | Director : Bill Lawrence | |
| Air Date : May. 06, 2009 |